Reproduction steps:
1. Open the attached "1408396.zip" project
2. Open the "SampleScene" Scene
3. Select the "Light 2D" GameObject
4. Enable the Shadows Strength setting (Inspector > "Light 2D" > Shadows > Strength)
5. Change the Sprite of the "Light 2D" GameObject to any Sprite (Inspector > "Light 2D" > Sprite)
6. Observe the Scene view

Expected result: All the Shadow Caster 2D shadows remain unchanged
Actual result: All the Shadow Caster 2D shadows disappear

Reproducible with: 12.1.5 (2021.2.14f1), 13.1.6 (2022.1.0b10), 14.0.0 (2022.2.0a7)
Could not test with: 7.7.1 (2019.4.36f1), 10.8.1 (2020.3.30f1) (Package errors after downgrade)

Notes:
- The issue disappears after changing the Sprite back to the original "Sparkle" Sprite
- If the issue doesn't reproduce with a selected Sprite, move the "Light 2D" GameObject around the Scene view