The game view is vertically flipped when the following conditions are met:

- The camera renders a material that uses GrabPass.
- HDR rendering is enabled on the camera property.
- The camera has an image effect that handles the UNITY_UV_STARTS_AT_TOP case.

For instance, this can be reproduced with the Stained BumpDistort shader and the VignetteAndChromaticAberration effect in the standard assets.

This issue is only reproducible when using Direct3D9 or Direct3D11.