Reproduction steps:
1. Open the attached project "AssetLoadTest.zip"
2. Open the Scene "main"
3. Build and Run

Expected result: The cube in the Scene continues to spin (Update() continues to work)
Actual result: The cube in the Scene stops to spin (Update() and the rest of the app freezes)

Reproducible with: 2020.1.0a21, 2020.3.14f1, 2021.1.14f1, 2021.2.0b1, 2022.1.0a1
Not reproducible with: 2019.4.28f1, 2020.1.0a20
Can't test with: 2018.4.36f1 (errors in the console)

Reproducible with:
VLNQA00001, Google Pixel 2 (Pixel 2), Android 11, CPU: Snapdragon 835 MSM8998, GPU: Adreno (TM) 540
VLNQA00277, Asus ROG Phone, Android: 8.1.0, CPU: Snapdragon 845 SDM845, GPU: Adreno (TM) 630
VLNQA00030, Lge LG G2, Android: 4.4.2, CPU: Snapdragon 800 MSM8974, GPU: Adreno (TM) 330
VLNQA00006, Samsung Galaxy S7, Android: 8.0.0, CPU: Exynos 8 Octa 8890, GPU: Mali-T880
VLNQA00121, Samsung Galaxy S9, Android: 9, CPU: Exynos 9 Series 9810, GPU: Mali-G72
N/A, Oneplus OnePlus Nord, Android: 10, GPU: Adreno (TM) 620
iPhone 12 (iOS 14.1) (3 / 5 times)

Not reproducible with:
iPad Pro 12.9 1st gen (iOS 13.4.1)
Samsung Note 9 (NA)
Editor and Player on Windows 10
Editor and Player on MacOS