Reproduction steps:
1. Open the attached project "ReproProj"
2. Open the “/Assets/Scenes/SampleScene.unity” Scene
3. In Menu bar click “Assets > Build AssetBundles”
4. Enter the Play Mode
5. Observe that penguin is present
6. Open Build Profiles (File > Build Profiles)
7. Build And Run
8. Observe the Player

Expected result: Penguin exists and no Errors are present
Actual result: Penguin is not present and Error “NullReferenceException: Object reference not set to an instance of an object“ is present

Reproducible with: 6000.0.66f1, 6000.3.5f1, 6000.4.0b5, 6000.5.0a5

Reproducible on:
Windows Standalone Player

Not reproducible on:
Play Mode

Testing environment: Windows 10 Enterprise 21H2
Not reproducible on: No other environment tested

Note:
- If you copy the Bundles folder into the "_Data" folder then the bundle is loaded correctly