How to reproduce:
1. Set one of your monitor's scale to the highest scale (170% or 200%) in Windows Display settings
2. Open the user's attached "LD47" project
3. Drag the Editor's window to your other monitor
4. Enter Play Mode
5. Press the Esc key to make the cursor visible

Expected result: The cursor is in the center of the Game View window
Actual result: The cursor is below or above the center of the Game View window or even outside the Game View window

Reproducible with: 2018.4.27f1, 2019.4.11f1, 2020.1.6f1, 2020.2.0b7, 2021.1.0a1

Tested with:
- 2560x1440, 225% (Main monitor) and 1920x1080, 100% (second monitor)

Note:
- Two monitors are needed to reproduce the issue
- Setting the main display's scale, and testing on the second display, the cursor appears below the center. Setting the second monitor's scale and testing on the main monitor makes the cursor appear above the center