Steps to reproduce:

1. Create new Unity project
2. Add random game object to the scene
3. Notice you can select anything you want in the scene view
4. Change color space to 'Linear'
5. Notice you can still select everyhting in the scene view
6. Close and reopen the project
7. Notice you can not select anything in the scene view (can navigate with hierarchy though)

If you change color space to 'Gamma' and reopen the project again, you can select everything in the scene view as expected.

Captured repro: http://screencast.com/t/cl38OhLGT