Steps to reproduce:

1. Open attached project
2. Open scene "TestScene"
3. In hierarchy, select "Animation" object which is parented by "Canvas"
4. Open animation window
5. Change animation clip from "Show" to "Hide"
6. Click on any keyframe visible in editor
7. Notice that animation clip is changed back to "Show"

Workaround: Click anywhere in sprite editor before clicking on keyframe

Note reproducible: 5.3.2p3
Reproduced with: 5.4.0b6