How to reproduce:
1. Open the attached project “IN_16486”
2. Open the “SampleScene” Scene
3. Select the “Cube” GameObject
4. In the Inspector unfold the “Unlit_Custom Shader” Material and change the X and Y value of “Tex 3 ST”
5. Save changes
6. Observe the Game View and unfolded “Unlit_Custom Shader” Material Tex 3 ST X/Y values

Expected result: changes are saved
Actual result: changes not saved

Reproducible with: 2020.3.40f1, 2021.3.10f1, 2022.1.17f1, 2022.2.0b8, 2023.1.0a11

Reproducible on: Windows 10 Pro

Note:
- After changing the version of Unity, the project needs to be closed and reopened in order to reproduce the issue
- After reproducing the issue once the project must be closed and reopened in order to reproduce the issue again on the same version