Version 5.4.0b22 (518a15457bf6)
Fri, 10 Jun 2016 20:29:39 GMT
Branch: 5.4/staging

1. What happened

Workaround available: use build settings menu

Build and Run hotkey and high level menu doesn't work on Win 8.1

2. How we can reproduce it using the example you attached

To repro:
1) Go to File
2) Use the hotkey (Cntl-B). Nothing happens.
3) Go to Build Settings and select Build. Project will build.
4) Go to Build Settings and select Build and Run. Project will build and deploy.