Toggling back and forth between whether or not VR is supported in Player settings and entering/exiting Play mode for each settings change results in overly large GUI Textures and GUI Text in Game view. The attached project contains some GUI Text and a 64 x 64 GUI Texture. However, the following steps make the GUI Texture 128 x 128 in Game view and the GUI Text becomes larger too:

Enter Play mode with VR Support enabled in Player settings.
Exit Play mode.
Toggle off VR Support in Player settings.
Enter Play mode.
Exit Play mode.
Toggle on VR Support in Play mode.
Enter Play mode.

Try saving, closing, and re-opening your project as a workaround.