*Steps to repro:*
# create a uXML document with a button, toggle and text field and save the file.
# in the main unity hierarchy, right-click and select UI Toolkit -> UI document
# in the new ui document created and your save file as the source asset
# enter play mode
# Left-clicks should work, quit play mode.
# Now change the layout using the layout dropdown on the top right corner and use default
# Enter play mode again and try to click.

*Result:*

left clicks no longer works

!click.gif!

Tested on 2023.2.0a1.117, works fine in 2023.1.0a26